Skip to Main Content

Systematic Review Process: Where to Search

This guide will assist teammates and researchers at Advocate Health - Midwest who are seeking information on and instructions for conducting systematic reviews.

Databases

You should plan to conduct your search in multiple databases. Clinical trials registries and grey literature sources are also searched for a comprehensive review. Advocate Health - Midwest Library offers a number of databases, but the library does not subscribe to everything. Some notable databases for systematic reviews include EMBASE, Web of Science, Scopus and PsycInfo. Consult with a librarian for suggestions on how you might access these resources.

Databases Available from Advocate Health - Midwest Library

Databases Available to Everyone

Grey Literature

Inclusion of grey literature into a systematic review is recommended in order to help minimize publication bias.

Examples of grey literature include:

  • conference abstracts
  • presentations and proceedings
  • regulatory data
  • unpublished trial data
  • government publications
  • reports (such as white papers, working papers, internal documentation)
  • dissertations and theses, patents, and policies and procedures

The inclusion of grey literature in systematic reviews is widely recognized as important and international organizations recommend the addition of grey literature in systematic reviews into their guidelines and manuals for working on reviews and meta-analyses.

You can start searching the grey literature with these resources:

  • NYAM Grey Literature Report

    New York Academy of Medicine collects grey literature from a list of healthcare related organizations, updated bi-monthly.

  • OAIster

    Catalog of millions of records representing open access resources from open access collections worldwide. OAIster includes more than 25 million records representing digital resources from more than 1,100 contributors.

  • Science.gov

    Gateway to over 50 million pages of authoritative selected science information provided by U.S. government agencies, including research and development results.

  • WorldWideScience.gov

    Global science gateway-accelerating scientific discovery and progress through a multilateral partnership to enable federated searching of national and international scientific databases.

  • List of Grey Literature Databases Mentioned by Cochrane

    Available through Cochrane Handbook for Systematic Reviews of Interventions (Go to Part2>General methods for Cochrane reviews>Searching for studies>Sources to search>Bibliographic databases>section 4.3.5 Other sources

  • MedlinePlus Directory of Organizations

    A list of organizations providing health information.

  • CADTH Grey Matters

    Checklist for national and international health technology web sites, clinical practice guidelines, health economics resources, drug and device regulatory agencies, drug class reviews, drug formulary web sites, clinical trial registries, Canadian health prevalence or incidence databases, etc.

Clinical Trials

Sample clinical trial databases:

  • ClinicalTrials.gov

    It is a registry and results database of publicly and privately supported clinical studies of human participants conducted around the world. Studies are generally submitted to the website (that is, registered) when they begin, and the information on the site is updated throughout the study. In some cases, results of the study are submitted after the study ends. This website and database of clinical studies is commonly referred to as a "registry" and "results database.

  • ISRCTN Register

    Registry of Current controlled Trials. It is a primary clinical trial registry recognized by WHO and ICMJE that accepts all clinical research studies (whether proposed, ongoing, or completed), providing content validation and curation and the unique identification number necessary for publication. All study records in the database are freely accessible and searchable.

  • WHO International Clinical Trials Registry Platform

    Access to data provided by clinical trial registries around the world that meet WHO criteria for content and quality.